Selected Publication

1.Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements

Li Z, Duan S, Hua X, Xu X, Li Y, Menolfi D, Zhou H, Lu C, Zha S, Goff, S, and Zhang Z.

Nature 2023, 623: 643-651.PMID: 37938774, DOI 10.1038/s41586-023-06711-3

2. H3K4me3 recognition by the COMPASS complex guides the restoration of this mark following DNA replication

Serra-Cardona A, Duan S, Yu C and Zhang Z
Sci Adv. 2022
PMID: 35544640 DOI: 10.1126/sciadv.abm6246

3. Epigenome Programming by H3.3K27M Mutation Creates a Dependence of Pediatric Glioma on SMARCA4

Mo Y, Duan S, Zhang X, Hua X, Zhou H, Wei HJ, Watanabe J, McQuillan N, Su Z, Gu W, Wu CC, Vakoc CR, Hashizume R, Chang K, Zhang Z
Cancer Discov. 2022.
PMID: 36305747 DOI: 10.1158/2159-8290.CD-21-1492

4. Stable inheritance of H3.3-containing nucleosomes during mitotic cell divisions

Xu X, Duan S, Hua X, Li Z, He R, Zhang Z
Nat Commun. 2022.
PMID: 35523900 DOI: 10.1038/s41467-022-30298-4

5. DNA polymerase α interacts with H3-H4 and facilitates the transfer of parental histones to lagging strands

Li Z, Hua X, Serra-Cardona A, Xu X, Gan S, Zhou Z, Yang WS, Chen C, Xu R and Zhang Z
Sci Adv. 2020.
PMID: 32923642 DOI: 10.1126/sciadv.abb5820

6. The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands

Gan H, Serra-Cardona A, Hua X, Zhou H, Labib K, Yu C, Zhang Z
Mol Cell. 2018.
PMID: 30244834, DOI: 10.1016/j.molcel.2018.09.001 

7. A mechanism for preventing asymmetric histone segregation onto replicating DNA strands

Yu C, Gan H, Serra-Cardona A, Zhang L, Gan S, Sharma S, Johansson E, Chabes A, Xu RM, Zhang Z
Science. 2018.
PMID: 30115745, DOI: 10.1126/science.aat8849 

8. Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109

Zhang L, Serra-Cardona A, Zhou H, Wang M, Yang N, Zhang Z, Xu RM
Cell. 2018.
PMID: 30057113, DOI: 10.1016/j.cell.2018.07.005

9. A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma

Chen X, Zhang M, Gan H, Wang H, Lee JH, Fang D, Kitange GJ, He L, Hu Z, Parney IF, Meyer FB, Giannini C, Sarkaria JN, Zhang Z
Nat Commun. 2018.
PMID: 30054476, DOI: 10.1038/s41467-018-05373-4

10. Checkpoint Kinase Rad53 Couples Leading- and Lagging-Strand DNA Synthesis under Replication Stress

Gan H, Yu C, Devbhandari S, Sharma S, Han J, Chabes A, Remus D, Zhang Z
Mol Cell. 2017.
PMID: 29033319, DOI: 10.1016/j.molcel.2017.09.018

11. RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells

Zhang H, Gan H, Wang Z, Lee JH, Zhou H, Ordog T, Wold MS, Ljungman M, Zhang Z
Mol Cell. 2017.
PMID: 28107649, DOI: 10.1016/j.molcel.2016.11.030

12. The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

Fang D, Gan H, Lee JH, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu RM, Westendorf JJ, Zhang Z
Science. 2016.
PMID: 27229140, DOI: 10.1126/science.aae0065

13. Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall.

Yu C, Gan H, Han J, Zhou ZX, Jia S, Chabes A, Farrugia G, Ordog T, Zhang Z.
Mol Cell. 2014
PMID: 25449133, DOI: 10.1016/j.molcel.2014.09.017

14. A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly

Han J, Zhang H, Zhang H, Wang Z, Zhou H, Zhang Z
Cell. 2013.
PMID: 24209620, DOI: 10.1016/j.cell.2013.10.014

15. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

Chan KM, Fang D, Gan H, Hashizume R, Yu C, Schroeder M, Gupta N, Mueller S, James CD, Jenkins R, Sarkaria J, Zhang Z
Genes Dev. 2013.
PMID: 23603901, DOI: 10.1101/gad.217778.113

16. Structural basis for recognition of H3K56-acetylated histone H3-H4 by the chaperone Rtt106

Su D, Hu Q, Li Q, Thompson JR, Cui G, Fazly A, Davies BA, Botuyan MV, Zhang Z, Mer G
Nature. 2012.
PMID: 22307274, DOI: 10.1038/nature10861

17. Acetylation of histone H3 lysine 56 regulates replication-coupled nucleosome assembly

Li Q, Zhou H, Wurtele H, Davies B, Horazdovsky B, Verreault A, Zhang Z
Cell. 2008.
PMID: 18662540, DOI: 10.1016/j.cell.2008.06.018

18. Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication

Han J, Zhou H, Horazdovsky B, Zhang K, Xu RM, Zhang Z
Science. 2007.
PMID: 17272723, DOI: 10.1126/science.1133234

Click here for a complete list of publications by Dr. Zhang.